Chiral Analysis: Advances in Spectroscopy, Chromatography and Emerging Methods

Chiral Analysis: Advances in Spectroscopy, Chromatography and Emerging Methods, Second Edition covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals, including chemistry graduate students, analytical chemists, organic chemists, professionals in the pharmaceutical industry, and others with an interest in chirality and chiral analysis. This thoroughly revised second edition covers several new, important areas of chiral analysis that have emerged since the first edition.

Three of the new methods provide higher sensitivity than can be realized with the current methods and are expected to become mainstream applications: cavity based methods offer vastly higher sensitivity than conventional polarimetric methods, microwave chiral detection provides unsurpassed sensitivity for identifying diastereomers, and the rotating electric field method offers a competing new approach for the separation of enantiomers. Another topic, chirality in extraterrestrial life, has not been discussed in any other book and is important for understanding the origin of life.

Offers the only book to cover both spectroscopic and separation methods in a single volume Provides an up-to-date and detailed review of the various techniques available, including new techniques that have emerged since the first edition Includes contributions from a range of leading experts in the field, now edited by award-winning chirality researcher Prasad Polavarapu

Chirality in Nature 1. Chiral Asymmetry in Nature 2. Remote Sensing of Homochirality: A Proxy for the Detection of Extraterrestrial Life Spectroscopic Methods and Analyses 3. Light Polarization and Signal Processing in Chiroptical Instrumentation 4. Chiroptical Spectroscopic Studies on Soft Aggregates and Their Interactions 5. Vibrational Optical Activity in Chiral Analysis 6. Raman Optical Activity 7. Chiral Molecular Tools Powerful for the Preparation of Enantiopure Compounds and Unambiguous Determination of Their Absolute Configurations by X-ray crystallography and/or 1H NMR diamagnetic anisotropy 8. Chiroptical Probes for Determination of Absolute Stereochemistry by Circular Dichroism Exciton Chirality Method 9. Chiral Analysis by NMR Spectroscopy: Chiral Solvating Agents 10. Chiroptical Spectroscopy of BiofluidsChromatographic and Electromigration methods 11. Chiral Gas Chromatography 12. Chiral Liquid Chromatography 13. Enantioseparations by Capillary Electromigration Techniques 14. Recent Developments in Chiral Separations by Supercritical Fluid Chromatography 15. Chiral Separation Strategies in Mass Spectrometry: Integration of Chromatography, Electrophoresis, and Gas-Phase MobilityEmerging Methods 16. Cavity-based Chiral Polarimetry 17. Quantitative Chiral Analysis by Molecular Rotational Spectroscopy 18. Chiral Rotational Spectroscopy 19. Chiral Analysis and Separation Using Molecular Rotation