Smell and Taste

Smell and Taste, Volume 164 focuses on recent clinical research regarding two of our primary chemical senses, smell and taste. This volume is the most comprehensive neurology book on disorders of smell and taste function. Its major sections include epidemiology, anatomy and physiology, and clinical assessment, including neuroimaging, clinical conditions affecting smell and taste function (e.g., autoimmune disorders, head trauma, diseases of the nose and mouth, etc.). The widespread use of olfactory testing in clinical trials searching for biomarkers of neurodegenerative diseases is reviewed, along with evidence that smell dysfunction can be an early marker in neurodegenerative diseases and autoimmune disorders.

Covers all aspects of disorders of taste and smell for beginning students of various disciplines (neurology, psychiatry, neuropsychology, otolaryngology)Teaches that smell and taste testing can be useful in differential diagnosis and can assess brain regions not normally assessed by traditional neurological or neuropsychological testsAddresses, in detail, recent evidence that smell loss is a better predictor of future mortality than dementia and even heart disease

SECTION I. BASIC PRINCIPLES A. Fundamentals 1. Epidemiology of smell and taste dysfunction

B. Morphophysiology of the olfactory and nasal trigeminal sensory systems 2. Anatomy of the olfactory system 3. Development of the human olfactory system 4. Anatomy of the olfactory mucosa 5. Olfactory receptor function 6. Central olfactory structures 7. Taste and smell processing in the brain 8. The intranasal trigeminal system 9. Cranial nerve 13

C. Morphophysiology of the gustatory and oral trigeminal systems 10. Anatomy and development of the human taste system 11. Taste receptor function 12. Central taste anatomy and physiology 13. The orotrigeminal system

SECTION II. CLINICAL ASPECTS A. Clinical assessment 14. Health histories and medical evaluations of patients with complaints of chemosensory dysfunction 15. Psychophysical testing of smell and taste function 16. Electrophysiological assessment of olfactory and gustatory function 17. Neuroimaging of smell and taste

B. Diseases and disorders 18. Diseases of the nasal cavity 19. Neurolocalization of taste disorders 20. Chemosensory dysfunction in neurodegenerative diseases 21. Systemic diseases and disorders 22. Toxic exposures and the senses of taste and smell 23. The influence of head injury on olfactory and gustatory function 24. Animal models of olfactory dysfunction in neurodegenerative diseases

C. Treatment and management of chemosensory disorders 25. Treatments for smell and taste disorders: A critical review