New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications

New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications examines the areas of biotechnology and chemical engineering, covering aspects of plants, bacteria and machines, and using microbes as factories. The book is aimed at undergraduates, post-graduates and researchers studying microbial secondary metabolites, and is an invaluable reference source for biochemical engineers working in biotechnology, manipulating microbes, and developing new uses for bacteria and fungi. The applications of secondary metabolites in biotechnology, pharmaceuticals, diagnostics and medical device development are extensively covered.

The book integrates the aforementioned frontline branches into an interdisciplinary research work to satisfy those working in biotechnology, chemical engineering, alternative fuel development, diagnostics and pharmaceuticals. Chapters related to important research work on applications of microbial secondary metabolites are written by specialists in the various disciplines from the international community.

Section A. Chemistry and biosynthesis 1. Peptide and peptide-derivative antibiotics 2. Polyketide derivatives 3. Other groups of bioactive products

Section B. Genetics and bioengineering 1. Preparation of high production microorganisms 2. Genetic manipulation of secondary metabolites producers 3. Bioengineering of secondary metabolites 4. Secondary metabolites: from metabolic engineering to synthetic biology/Metabolomics for secondary metabolites

Section C. Obtaining new bioactive secondary metabolites 1. Isolation from natural resources 2. Producers of bioactive compounds 3. Semi-synthetic and synthetic bioactive products 4. Hybrid bioactive products and combinatorion biosynthesis

Section D. Regulation of secondary metabolites production 1. Growth phases of microbial culture 2. Control of fermentation by basal nutrients 3. How signals from the medium are received 4. Regulation by low molecular compounds 5. Autoregulators 6. Regulation by metal ions

Section E. Resistance to secondary metabolites 1. Resistance of bioactive secondary metabolites producers 2. Resistance in pathogenic microorganisms