Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology.

Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalystsIncludes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processesIdentifies new targets for drug design studiesProvides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Preface

PART I INTRODUCTION 1. Carbonic Anhydrases: an overview

PART II CARBONIC ANHYDRASES AS DRUG TARGETS 2. Human Carbonic Anhydrases: catalytic properties, structural features and tissue distribution 3. Carbonic Anhydrase I 4. Carbonic Anhydrase II as target from drug design 5. Carbonic Anhydrase III 6. Carbonic Anhydrase IV 7. The structure, physiological role and potential medicinal applications of Carbonic Anhydrase V 8. Secreted Carbonic Anhydrase Isoenzyme VI 9. Carbonic Anhydrase VII 10. Tumor associated carbonic Anhydrases IX and XII 11. Carbonic anhydrase XIII 12. Carbonic anhydrase XIV: structure, functions and potential medical applications 13. Acatalytic Carbonic anhydrases (CAs VIII, X, XI) 14. Beta-class Carbonic anhydrases: general features and medical implications 15. Bacterial Carbonic Anhydrases as drug targets

PART III CARBONIC ANHYDRASES FOR BIOTECHNOLOGICAL APPLICATIONS 16. Engineered mammalian Carbonic Anhydrases for CO2 capture 17. Carbonic anhydrases from extremophiles and their biotechnological applications 18. Carbonic Anhydrases of environmentally and medically relevant anaerobic prokaryotes 19. Delta Carbonic anhydrases: structure, distribution and potential roles 20. CDCA1 from Thalassiosira weissflogii as representative member of zeta-class CAs: general features and biotechnological applications of anhydrases 21. Carbonic anhydrases as esterases and their biotechnological applications