Functional Neural Transplantation III: Primary and Stem Cell Therapies for Brain Repair, Part I

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

1. Preface

Stephen Dunnett and Anders Björklund

2. Transplantation in the Future

Fred H. Gage

3. Ethical Challenges for Using Human Cells in Clinical Cell Therapy

Göran Hermerén

4. Banking Stem Cells for Research and Clinical Applications

Glyn Stacey

5. Survival, Differentiation and Connectivity of Ventral Mesencephalic Dopamine Neurons following Transplantation

Lachlan Thompson and Anders Björklund

6. Electrophysiological Investigations of Synaptic Connectivity between Host and Graft Neurons

Jan Tønnesen and Merab Kokaia

7. Nigral Grafts in Animal Models of Parkinson’s Disease. Is Recovery beyond Motor Function Possible?

Mariah J. Lelos, Eilís Dowd and Stephen B. Dunnett

8. L-DOPA- and Graft-Induced Dyskinesia following Transplantation

Emma L. Lane and Christian Winkler

9. Current Status of Clinical Trials of Neural Transplantation in Parkinson’s Disease

Jonathan R Evans, Sarah L Mason and Roger A Barker

10. In vivo Imaging of the Integration and Function of Nigral Grafts in Clinical Trials

Marios Politis and Paola Piccini

11. Neuropathology in Transplants in Parkinson’s Disease: Implications for Disease Pathogenesis and the Future of Cell Therapy

Patrik Brundin and Jeffrey H. Kordower

12. Derivation of Dopaminergic Neurons from Pluripotent Stem Cells

Lorenz Studer

13. Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy

Oliver Cooper, Malin Parmar and Ole Isacson

14. Skilled Motor Control for the Preclinical Assessment of Functional Deficits and Recovery following Nigral and Striatal Cell Transplantation

Alexander Klein and Ian Q. Whishaw

15. Role of Experience, Training and Plasticity in the Functional Efficacy of Striatal Transplants

Máté D. Döbrössy and Guido Nikkhah

16. In vivo Imaging of Integration and Function of Striatal Grafts in Rodent and Non-Human Primate Animal Models

Philippe Hantraye and Romina Aron Badin

17. Clinical Trials of Neural Transplantation in Huntington’s Disease

Anne E. Rosser and Anne-Catherine Bachoud-Lévi

18. Derivation of Striatal Neurons from Human Stem Cells Pedro Viegas, Camille Nicoleau and Anselme L. Perrier