Recent Advances in Parkinsons Disease: Part II: Translational and Clinical Research

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applicationsLeading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Section I: Animal models of PD

1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
2. Neurotoxic in vivo models of Parkinson’s disease: recent advances - Timothy Greenamyre & Jason R. Cannon
3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease - Stephen B. Dunnett & Mariah Lelos
4. Genetic mouse models of Parkinson’s disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson’s disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past, present and future - Susan Fox & Jonathan Brotchie

Section II: Exploring PD with brain imaging

8. Abnormal Metabolic Brain Networks in Parkinson’s Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
9. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
10. Brain imaging after neural transplantation - Paola Piccini & Marios Politis
11. Imaging non-motor aspects of Parkinson’s disease - David Brooks & Nicola Pavese

Section III: Frontiers in PD treatment

12. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll
13. Neurotrophic Factor Therapy for Parkinson’s disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
14. Neural grafting in Parkinson’s disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar
15. Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler
16. Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce
17. The challenge of Non-Motor Symptoms in Parkinson´s Disease - Ray Chaudhuri & Per Odin