Diabetes and the Nervous System

This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson’s disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.

Offers a unique emphasis on the neurological manifestations of diabetesProvides thorough coverage of the clinical, experimental, mechanistic, therapeutic, peripheral, and central aspects of diabetic neuropathyEdited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Section 1. CLINICAL IMPACT OF DIABETES ON THE NERVOUS SYSTEM 1. Epidemiology of polyneuropathy in diabetes and prediabetes 2. Clinical features of diabetic polyneuropathy 3. Focal and entrapment neuropathies 4. Diabetic radiculoplexus neuropathies 5. Painful diabetic neuropathy: clinical aspects 6. Diabetic autonomic neuropathy 7. Motor neuropathy 8. Diabetic neuropathy and foot ulceration 9. Glucose intolerance and neuropathy 10. Diabetic neuropathy in children 11. Cognitive disorders in diabetic patients 12. Stroke and diabetes mellitus 13. Neurological infections in diabetes mellitus 14. Recognition and management of psychosocial issues in diabetic neuropathy 15. Overview of diabetes management in patients with neurological disorders 16. Sexual dysfunction in diabetes

Section 2. DIAGNOSTIC AND THERAPEUTIC APPROACHES TO DIABETIC NEUROLOGICAL COMPLICATIONS 17. Electrophysiological testing in diabetic neuropathy 18. Diabetic neuropathy and nerve structure 19. Epidermal innervation in diabetes 20. Clinical and diagnostic features of small fibre damage in diabetic polyneuropathy 21. CNS imaging in cerebrovascular and white matter disease 22. Therapy for diabetic neuropathy: an overview 23. Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy

Section 3. FUNDAMENTAL STUDIES OF DIABETIC NEUROSCIENCE 24. Neuroscience of glucose homeostasis 25. Mechanisms of disease 1. Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes 26. Mechanisms of diabetic neuron damage: molecular pathways 27. Mechanisms of diabetic neuropathy 3: Schwann cells 28. Mechanisms of disease: axon dysfunction 29. Mechanisms of disease: role of neurotrophins in diabetes and diabetic neuropathy 30. Experimental motor neuropathy in diabetes 31. Ischemic neuropathy 32. Diabetes and neurodegeneration in the brain 33. Neurological damage in hypoglycemia 34. Painful neuropathy-mechanisms 35. Insights into the pathogenesis and treatment of painful diabetic neuropathy 36. Autonomic neuropathy in experimental models of diabetes mellitus