Traumatic Brain Injury, Part I

The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.

Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injuryExplores cellular and molecular mechanisms as well as genetic predictors of outcomeOffers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and moreState-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Section 1 Risk and Predisposition 1. Epidemiology  2. Classification of traumatic brain injury: past, present and future  3. Genetic predictors of outcome following TBI

Section 2 Pathology and Mechanisms of Traumatic Brain Injury 4. The neuropathology of traumatic brain injury  5. Cellular and Molecular Mechanisms of Injury and Spontaneous Recovery  6. Injury biomechanics, neuropathology, and simplified physics of explosive blast and impact mild traumatic brain injury  7. Cellular biomechanics of central nervous system injury  8. Animal models of traumatic brain injury

Section 3 Special Considerations 9. Mild traumatic brain injury  10. Acute sports-related traumatic brain injury and repetitive concussion  11. Brain injury from explosive blast: description and clinical management   12. Surgical management of civilian gunshot wounds to the head  13. Acute Loss of Consciousness  14. Systemic manifestations of traumatic brain injury  15. Special Considerations in Infants and Children

Section 4 Current and Emerging Diagnostic Tools 16. Biomarkers  17. Current and future diagnostic tools for traumatic brain injury: CT, conventional MRI, and diffusion tensor imaging  18. Using fMRI and EEG to detect consciousness after severe brain injury   19. Resting Functional Imaging Tools: (MRS, SPECT, PET and PCT)  20. Advances in imaging explosive blast mild traumatic brain injury  21. Electrophysiological recordings in traumatic brain injury

Section 5 Management and Treatment 22. Neuroprotection for traumatic brain injury  23. The prehospital management of traumatic brain injury  24. Acute Management of Military-Related Injury (PHI & Blast)  25. Clinical Management of the Minimally Conscious State   26. Rehabilitation after traumatic brain injury  27. Long-Term Social Integration and Community Support   28. Recent developments in clinical trials for the treatment of traumatic brain injury