Oxidative Stress and Neurodegenerative Disorders

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.

* Contains the latest information on the subject of neurodegenerative disorders
* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

1
Advances in our understanding of Neurodegeneration.
Kurt A. Jellinger.

2
Mitochondrial mutagenesis in the brain in forensic and pathological research
Nicole von Wurmb-Schwark

3
Genetic and environmental factors in neurodegenerative diseases
Fabio Coppedè and Lucia Migliore

4
Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders
Vittorio Calabrese, Cesare Mancuso, Carlo De Marco, Anna Maria Giuffrida Stella and D. Allan Butterfield.

5
Oxidative Stress and Radiation-induced Late Normal Tissue Injury
M.E.C. Robbinsand W. Zhao

6
Oxidative stress-induced death in the nervous system: cell cycle dependent for independent?
Brett C. Langley

7
Redox imbalance in Parkinson’s disease.
Daniela Berg.

8
Genes and Oxidative Stress in Sporadic and Familial Parkinsonism : cDNA Microarray Studies.
Youdum M.B.H., Grunblatt E, Mandel S, Riederer P.

9
Down syndrome, antioxidant balance and the “gene dosage effect” hypothesis.
Judy de Haan, P.J. Crack, M. Pritchard and I. Kola

10
The role of levodopa in the chronic neurodegenerative disorder Parkinson’s disease.
Thomas Muller.

11
Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients.
Prof. K. Christou, K.I. Gourgoulianis.

12
The Key Role of Oxidative Stress in Alzheimer Disease.
George Perry, Mark A. Smith, Paula I. Moreira, Akihiko Nunomura, Kazuhiro Honda, Gjumrakch Aliev, Gemma Casadesus, Xiongwei Zhu.

13
The role of oxidative stress in the pathogenesis of multiple sclerosis: Current state.
Nirit Lev, Yossi Gilgun-Sherki, Daniel Offen, Eldad Melamed.

14
Oxidative stress and neuroinflammation in Alzheimere’s disease and amyotrophic lateral sclerosis: From Biology to Therapeutic Strategies.
Molina Mhatre, Kenneth Hensley.

15
Oxidative Stress in Stroke.
Margarita L. Alexandrova and Petyo G. Bochev.

16
Hyperoxidation of the two catechol amines, Depamine and Adrenaline: Implications for the Etiiologies and Treatment of Encephalitis Lethargica, Parkinson;s disease, Multiple sclerosis, Amyotrophic Lateral Sclerosis and Schizophrenia.
Harold D. Foster, Abram Hoffer.

17
The role of metals and their effect on oxidative stress in amyotrophic lateral sclerosis.
Maria Teresa Carr.

18
Neurotransmission and coexistence of neurotransmitters in Parkinson’s disease.
G.Ali Qureshi.

19
Manganese-Induced Oxidative Stress: Truth or Fiction
Allison W. Dobson

20
Prospects for Antioxidant Therapy in Mild Cognitive Impairment and Alzheimer’s Disease.
Mark A. Smith.

21
An assessment of the chances of antiapoptotic drug therapy in patients with neurodegenerative disorders.
Peter C. Waldmeier.

22
Role of Antioxidant Activity of Estrogens in their Potent Neuroprotection.
James W. Simpkins, Ph.D. and Evelyn Perez, Ziaofei Wang.

23
Diet, Herbs, and Nutritional Protection Against Oxidative Stress in Neurological Diseases.
Carlos Kusano Bucalen Ferrari, PhD

24
Diabetic Neuropathy: Pathogenesis and Treatment.
Maria Siemionow, MD, PhD, DsC Yalcin Kulahci, MD, Galip Agaoglu, MD

25
Green and Black Tea in Brain Protection.
Elzbieta Skrzydlewska, Justyna Ostrowska, Wojciech Lluczaj, Agnieszka Augustyniak.

26
Environmental and genetic interactions: key to sporadic Parkinson’s disease?
Fai. TSANG, & Tuck Wah SOONG

27
Prevention and Therapy of Neurodegenerative Disorders: Role of Nutritional Antioxidants.
Ennio Esposito, MD, Vincenzo Di Matteo, Massimo Pierucci, and Giuseppe Di Giovanni.

28
Genetics of Parkinson’s disease.
Yue Huang, Piu Chan, Glenda Halliday.

29
Biomarkers of hypoxic brain injury.
Buonocore Giuseppe

30
Role of Iron, Zinc and Copper in Parkinson patients.
G.Ali Qureshi, S. Ali Shuja, and S. H.Parvez

31
Oxidative stress in phagocytic cell : changes with age and effect of melatonin
Carmen Barriga, M.P. Terron, H.Parvez, J.Cubero, D.Narciso, S.D.Paredes, S.Sanchez and A.B.Rodriquez