Neurobiology of Psychiatric Disorders

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.

Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatmentIncludes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disordersA "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

1. Psychiatry and neuroscience history; 2. Receptor signaling and the cell biology of synaptic transmission; 3. Human genetics of schizophrenia; 4. Neurological and psychiatric aspects of emotion; 5. Research methods: cognitive neuropsychological methods; 6. Structural imaging in psychiatric disorders; 7. Human functional neuroimaging; 8. Neurotransmitters and neuropeptides in depression; 9. Animal models of psychiatric disorders; 10. Psychiatric epidemiology; 11. Emerging methods in the molecular biology of neuropsychiatric disorders; 12. Clinical psychoneuroimmunology; 13. Psychiatric rating scales; 14. Unipolar depression; 15. Bipolar disorder; 16. The neurobiology and treatment of late-life depression; 17. Seasonal affective disorder; 18. Biological and clinical framework for post-traumatic stress disorder; 19. Generalised anxiety disorder; 20. Panic disorder; 21. Obsessive compulsive disorder; 22. Attention deficit hyperactivity disorder; 23. Autism and related disorders; 24. Substance abuse disorders; 25. Cognitive impairment in schizophrenia: profile, course and neurobiological determinants; 26. Eating disorders: anorexia and bulimia nervosa; 27. Personality disorders; 28. Psychiatric, non motor aspects of Parkinson’s disease; 29. Stroke; 30. Huntingdon’s disease; 31. Sleep disorders; 32. Depression and cardiovascular disorders; 33. Psychiatric disorders among cancer patients; 34. Chronic fatigue syndrome; 35. Neurocognitive deficits in patients with human immunodeficiency virus infection; 36. Gastrointestinal disorders; 37. Role of psychotherapy in the management of psychiatric diseases; 38. Pharmacology and neuroimaging of antidepressant action; 39. Antipsychotic drugs; 40. Anxiolytics; 41. Brain stimulation therapies for neuropsychiatric disease; 42. Chronotherapeutics, light and wake therapy as a class of interventions for affective disorders; 43. Pharmacogenetics of antidepressants and mood stabilisers