Aluminium and Alzheimers Disease: The Science that Describes the Link

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.

This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

Preface. Why is Research into Aluminium and Life Important? (C. Exley). Selected Papers. Aluminium-Induced Bone Disease: Implications for Alzheimer's Disease (K. Abreo). The Epidemiology of Aluminium and Alzheimer's disease (V. Rondeau, D. Commenges). Aluminium-Induced Alteration of Phosphoinositide and Calcium Signalling (W.R. Mundy, T.J. Schafer). The Interaction of Aluminium with Peptides and Proteins (T. Kiss, M. Hollósi).