Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more.

Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

1. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative diseases

Kenneth Maiese

2. Antidiabetic drugs for Alzheimer´s and Parkinson´s diseases: Repurposing insulin, metformin and thiazolidinediones

Susana Cardoso and Paula I. Moreira

3. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases

Christian Hölscher

4. Repurposing GLP1 agonists for neurodegenerative diseases

Ioanna Markaki, Kristian Winther, Sergiu-Bogdan Catrina and Per Svenningsson

5. A role for Sodium Glucose coTransporter 2 inhibitors (SGLT2i) in the treatment of Alzheimer's disease?

Russell Esterline, Jan Oscarsson and Jeffrey Burns

6. Ketotherapeutics for neurodegenerative diseases

Nicholas G. Norwitz, Javier Gilbert Jaramillo, Kieran Clarke and Adrian Soto

7. Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases

Yahyah Aman, Brent Ryan, Silje Bøen Torsetnes, Anne-Brita Knapskog, Leiv Otto Watne, William A. McEwan and Evandro Fei Fang

8. Cellular senescence in aging and age-related disorders: Implications for neurodegenerative diseases

Erin O. Wissler Gerdes, Yi Zhu, Bettina M. Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkonia and James L. Kirkland

9. Harnessing neurogenesis in the adult brain—A role in type-2-diabetes mellitus and Alzheimer’s disease

Orly Lazarov, Richard D. Minshall and Marcelo G. Bonini

10. Hormesis: A therapeutic strategic approach in the treatment of neurodegenerative disease