Autophagy in Health and Disease

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more.

Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagyIncludes critical discussions of autophagy in the context of each major human disorderModels autophagy-related human pathologies in lower eukaryotes

Preface - Autophagy: An old mechanism with new challenges ahead Aitziber Buqué and Lorenzo Galluzzi 1. Nucleophagy mediators and mechanisms Margarita-Elena Papandreou and Nektarios Tavernarakis 2. Scaffold proteins in bulk and selective autophagy Christopher Eickhorst, Mariya Licheva and Claudine Kraft 3. A global view of the miRNA-mitophagy connexion Flavie Strappazzon 4. Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications Andrew Thorburn 5. Autophagy in immunity Christian Münz 6. Autophagy in cardiovascular health and disease  Mahmoud Abdellatif, Senka Ljubojevic-Holzer, Frank Madeo and Simon Sedej 7. Autophagy in kidney disease: Advances and therapeutic potential Divya Bhatia and Mary E. Choi 8. Autophagy in chronic lung disease Alexandra C. Racanelli, Augustine M.K. Choi and Mary E. Choi 9. Autophagy contribution to motor neuron disease pathology Natalia Rodríguez-Muela 10. Strategies employed by viruses to manipulate autophagy Nilima Dinesh Kumar, Jolanda M. Smit and Fulvio Reggiori 11. Crinophagy mechanisms and its potential role in human health and disease Tamás Csizmadia and Gábor Juhász 12. Autophagy role in environmental pollutants exposure Gemma G. Martínez-García and Guillermo Mariño 13. Genetic defects of autophagy linked to disease Milana Fraiberg and Zvulun Elazar 14. C. elegans to model autophagy-related human disorders Shi Q. Wong, Anita V. Kumar, Joslyn Mills and Louis R. Lapierre 15. Drosophila as a model to understand autophagy deregulation in human disorders Donna Denton, Louise O'Keefe and Sharad Kumar