Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance.

Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges.

Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

1. Introductory Chapter
2. Tumor Metabolic Reprogramming in Therapeutic Resistance
3. Development of novel antiandrogens to overcome castrate resistant prostate cancer
4. Microenvironmental regulation of cancer response to therapy and therapy resistance
5. Revisiting immunogenic cell death to overcome treatment resistance in cancer immunotherapy
6. Preventing Phenotypic Plasticity in Cancer to Mitigate Therapy Resistance
7. Overcoming drug resistance in cancer with targeted radionuclide therapy
8. The PI3K pathway and chemotherapy resistance
9. Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia
10. Escape from apoptosis: Anastasis as a potential mechanism of cancer drug resistance
11. From genetic data and structures to drug development: new approaches to targeting Eph receptors
12. Overcoming Therapeutic Resistance in Glioblastoma: a major clinical challenge