Actin Cytoskeleton in Cancer Progression and Metastasis - Part B

Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the  International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more.

Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biologyOffers a wide range of perspectives for basic and translational researchDiscusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications

1. Actin dynamics during tumor cell dissemination Jose J. Bravo-Cordero 2. Actin cytoskeleton remodeling during cancer cell migration Antonina Alexandrova 3. Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer Michelle Dawson 4. The many roles of actin in the nucleus Stefan Zahler 5. The emerging role of nuclear actin and myosin in the transcriptional response to DNA damage Piergiorgio Percipalle 6. The microenvironment and cytoskeletal remodeling in tumor cell invasion Tafazzoli Shadpour 7. Mechanics of actin filaments in cancer onset and progress Tafazzoli Shadpour 8. Actin cytoskeleton regulators at invadopodia Clement Thomas 9. Novel facets of Glioblastoma invasion Simone Niclou