Actin Cytoskeleton in Cancer Progression and Metastasis - Part A

Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response.

Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biologyOffers a wide range of perspectives for basic and translational researchDiscusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications

1. Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion

Kyle M. Alpha, Weiyi Xu and Christopher E. Turner

2. Nuclear actin in cancer biology

Stefan Zahler

3. Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity

Tomas Venit, S. Raza Mahmood, Martin Endara-Coll and Piergiorgio Percipalle

4. The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer

Elisabeth Schaffner-Reckinger and Raquel A. C. Machado

5. Profilin choreographs actin and microtubules in cells and cancer

Morgan L. Pimm, Jessica Hotaling and Jessica L. Henty-Ridilla

6. Mechanics of actin filaments in cancer onset and progress

Mohammad Tafazzoli-Shadpour, Ehsan Mohammadi and Elham Torkashvand