Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates

Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development.

This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry.

Highlights important features of bacterial glycoproteinsIllustrates modern chemical synthesis and structural analysis of bacterial glycansDemonstrates the importance of carbohydrate chemistry for the synthesis of lipopolysaccharides and teichoic acidCovers recent findings on glycan ligationGives an overview of the most recent developments on carbohydrate-based vaccines

I. Advances in chemical synthesis and biosynthesis of bacterial glycans 1. Prokaryotes: Sweet proteins do matter 2. Glycan ligation reactions in the periplasmic space 3. Synthesis of bioactive lipid A and analogues 4. Synthesis of lipopolysaccharide core fragments 5. Synthesis of oligosaccharides related to potential bioterrorist pathogens 6. Synthetic teichoic acid chemistry for vaccine applications 7. NMR characterization of bacterial glycans and glycoconjugate vaccines

II. Synthetic carbohydrate-based vaccines: present and future 8. Glycoconjugate vaccines, production and characterization 9. Antifungal glycoconjugate vaccines 10. Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development 11. Glyconanoparticles as versatile platforms for vaccine development: A mini review