pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field.

Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.

Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modelingExplains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehensionDiscusses novel targets to explore new possibilities that enhance research in the field

PART I General overview of the topic: An update 1. General introduction about general mechanisms of resistance in cancer (hypoxia, efflux pumps, tumoral microenvironment) and use of chemosensitizers in association with drugs already in the market 2. Clinical studies analysis 3. Combination therapy 4. Oncoimmunology

PART II Chemosensitizing agents with a validated mechanism of action 5. pH regulators of the tumoral microenvironment 6. Proton Pump Inhibitors (PPIs) and other pH buffering agents 7. Selective hCA IX and XII inhibitors 8. Epigenetic modulators 9. Photosensitizing agents 10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil) 11. Metalloproteinase inhibitors (e.g., ADAM17) 12. Kinesin inhibitors 13. Drug repurposing 14. Innovative and putative targets for chemosensitizers 15. Patent survey on chemosensitizers

PART III Chemosensitizing agents from natural sources 16. Natural compounds as chemosensitizers: a lesson from plants 17. Natural compounds: from food to clinic

PART IV Chemosensitizing agents: Computational tools and technological approaches 18. Virtual screening and chemoinformatics of new library of chemosensitizers 19. Nanostructures overcoming cancer resistance