Combination Therapy Against Multidrug Resistance

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant

Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistancePresents a broad scope to understand fully the ways to apply combined therapy to multidrug resistanceProvides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

1 Combination therapy: Current status and future perspectives Manzoor Ahmad Malik, Mohmmad Younus Wani, and Athar Adil Hashmi

2 Combination therapy against multidrug resistance Musa Marimani

3 Multidrug resistance and the prospects of combination therapy A. Balakrishna, G. Sravya, T.V. Surendra, C. Suresh Reddy, Grigory V. Zyryanov, and N. Bakthavatchala Reddy

4 Combination therapy against human infections caused by Candida species Indresh Kumar Maurya, Ruchi Badoni Semwal, and Deepak Kumar Semwal

5 Metallodrug-driven combination chemotherapy in cancer treatment Afzal Hussain, Mohamed Fahad AlAjmi, Prince F. Iqbal, and Waseem A. Wani

6 Combination antituberculosis therapy: Opportunities and challenges to combat drug-resistant tuberculosis Sudarkodi Sukumar, Md. Zafaryab, Md. Khurshid Alam Khan, Krishnan Hajela, and Mohammad Nasiruddin,

7 Synergistic effect of drugs against multiple drug-resistant swine pathogen Streptococcus suis Shama Khan

8 Combination therapy and multidrug resistance in malaria parasite Abdul Hafiz, Mahmood A. Alam, Othman A. Alghamdi, and Arif Mohammed

9 Combination therapy as an effective tool for treatment of drug-resistant viral infections Musa Marimani, Aijaz Ahmad, and Adriano Duse

10 Combination therapy against human infections caused by viruses Rifat Munir

11 Phenotype screenings of drugs for combination therapy against multidrug resistance Arif Mohammed and Othman A. Alghamdi

12 New approaches for targeting drug resistance through drug combination Shailesh Kumar Singh, Arif Mohammed, Othman A. Alghamdi, and Syed Masood Husain