Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Neurodegenerative Disease Research and Commonalities with Metabolic Diseases

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer’s Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.

Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.

1. Status and future directions of clinical trials in Alzheimer’s disease

Germán Plascencia-Villa and George Perry

2. Tracking the potential involvement of metabolic disease in Alzheimer's disease—Biomarkers and beyond

Jose A. Luchsinger and Henrik Zetterberg

3. Brain glucose and ketone utilization in brain aging and neurodegenerative diseases

Dimitrios Kapogiannis and Konstantinos I. Avgerinos

4. Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease—Learnings from brain imaging biomarkers

Kerstin Heurling, Edvin Johansson and Antoine Leuzy

5. APOE and metabolic dysfunction in Alzheimer’s disease

Lance A. Johnson

6. Status and future directions of clinical trials in Parkinson's disease

Grażyna Söderbom

7. Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching

Mark P. Mattson

8. The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's disease

Russell H. Swerdlow

9. MAM and C99, key players in the pathogenesis of Alzheimer’s disease

Marta Pera, Jorge Montesinos, Delfina Larrea, Rishi R. Agrawal, Kevin R. Velasco, Irina G. Stavrovskaya, Taekyung D. Yun and Estela Area-Gomez

10. Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson’s disease genetic risk

Ria Thomas, Penelope J. Hallett and Ole Isacson

11. Endosomal-lysosomal dysfunction in metabolic disorders and Alzheimer's disease

Michael F. Almeida, Ben A. Bahr and Stephen T. Kinsey

12. Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases

Paul Edison

13. The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseases

Grażyna Söderbom and Bai-Yun Zeng

14. Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases

S. Kendall Smith and Erik S. Musiek

15. The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases