Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells.

From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.

Presents a systemic summary of molecular mechanisms for a quick and in-depth understandingUpdates current trends in the field with pioneering information on drug resistanceEncompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

1. Drug resistence in colorectal cancer: General aspects

2. Drug transporters in the development of multidrug resistance in colorectal cancer

3. Role pf colorectal cancer stem cells in resistance to apoptosis and treatment in colorectal cancer

4. Serrated lesions and stem cells on drug resistance and colon cancer

5. Development of novel microRNA-based therapeutics platform for colorectal cancer

6. Chemo-sensitizing agents for naturalorigin for colorectal cancer: Pharmacokinetics approaches

7. Induction of programmed necrosis by phytochemicals in colorectal cancer

8. Predictive biomarkers of drug resistance in colorectal cancer - Recent updates

9. Raclb: An emerging therapeutic target for chemoresistance in colorectal cancer

10. Nanotechnology-based targeted drug delivery systems and drug resistance in colorectal cancer

11. Targeting colorectal cancer via nanodrug delivery systems