Gene Environment Interactions: Nature and Nurture in the Twenty-first Century

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders.

Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.

Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studiesIlluminates environmental factors affecting disease-gene etiology and treatmentSupports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

1. Interacting with the environment receiving and interpreting signals 2. Environment as Provider 3. Human Evolution and adaptations to environments and to pathogen encounters 4. Genetic mechanisms in environmental adaptations 5. Epigenetics and the regulatory genome 6. The microbiome: The external life forms within 7. Human development, behaviors, impacts of environment and genetic variations 8. Joint Roles of Genes and Environment in etiology of specific diseases 9. Personalized Precision Medicine 10. Identifying and mitigating effects of Harmful factors in the Intrinsic or Extrinsic Environment 11. Questions relating to climate change