Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside

Progress in Molecular Biology and Translational Science, Volume 167, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to Models and Biological Targets in Drug Discovery for Attention Deficit Hyperactivity Disorder, Novel Targets for Parkinson-Depression Co-morbidity. Utility of Cannabidiol (CBD) in Neuropsychiatric Disorders: A Short Review of the Recent Pre-clinical and Clinical Findings, The Many Sides of Microglia in Alcohol Use Disorders, Stress, Anxiety, Molecular Targets and More, Calcineurin Signaling in Psychiatric Disorders, Emerging Evidence for the Role of Pituitary Adenylate Cyclase- Activating Peptide (PACAP) in Neuropsychiatric Disorders, and more.

Includes comprehensive coverage of molecular biologyPresents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information providedContains contributions from renowned experts in the field

1. Novel targets for parkinsonism-depression comorbidity Yousef Tizabi, Bruk Getachew, Antonei B. Csoka, Kebreten F. Manaye and Robert L. Copeland 2. Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings Sonja Elsaid, Stefan Kloiber and Bernard Le Foll 3. Stress, psychiatric disorders, molecular targets, and more Fatin Atrooz, Hesong Liu and Samina Salim 4. Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease Ramsha Shams, Naren L. Banik and Azizul Haque 5. Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders Patrick J. Ronan, Sarah A. Flynn and Thomas P. Beresford 6. Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders Kabirullah Lutfy and Shankar Gollapudi 7. Glial mechanisms underlying major depressive disorder: Potential therapeutic opportunities Shafiqur Rahman and Sami Alzarea 8. Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders Jennifer K. Melbourne, K. Ryan Thompson, Hui Peng and Kimberly Nixon 9. Microglia as possible therapeutic targets for autism spectrum disorders Megumi Andoh, Yuji Ikegaya and Ryuta Koyama