Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.

Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful.

Written by scientists with extensive industrial experience in drug discoveryProvides a balanced view of the field, including its challenges and future directionsIncludes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

1. What are drugs and why are they required? 2. Drugs against gram-negative bacteria 3. Drugs targeting gram-positive bacteria 4. Drug repurposing against bacteria 5. Drugs against M. tuberculosis 6. Drugs against TB and Bioweapons 7. New approaches to drug discovery: Peptides/quorum sensing/virulence 8. New strategies and targets for antibacterial discovery 9. Targeting efflux pumps for AMR 10. Discovering antibiotics from Phages 11. Drugs against non-tuberculous mycobacteria