Nanotechnology for Oral Drug Delivery: From Concept to Applications

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.

Highlights the relevance of oral drug delivery in the clinical settingCovers the most recent advances in the field of nanotechnology for oral drug deliveryProvides the scientific community with data that can facilitate and guide their research

Part I: Biological aspects and properties of nanomaterials for oral drug delivery 1. Oral drug delivery: overview 2. Organization of the intestinal mucosa and barriers to oral drug delivery 3. Nanomaterials for oral drug administration 4. Mucoadhesive and mucus-penetrating polymers for drug delivery 5. Size, shape and surface charge considerations of orally delivered nanomedicines 6. Modified drug release: current strategies and novel technologies for oral drug delivery 7. Delivery platforms for oral drug administration 8. (Trans)Buccal drug delivery

Part II: Advanced technologies for oral delivery applications 9. Spray drying for the formulation of oral drug delivery systems 10. Microdevices to successfully deliver orally administered drugs 11. Batch and microfluidic reactors in the synthesis of enteric drug carriers 12. 3D printing in oral drug delivery

Part III: Methods for the evaluation of oral drug delivery systems 13. 3D intestinal models towards a more realistic permeability screening 14. In vitro relevant information for the assessment of nanoparticles for oral drug administration 15. In vivo testing of orally delivered nanoparticles

Part IV: Pharmaceutical industry perspective 16. Industrial perspectives and future of oral drug delivery