Mechanobiology: From Molecular Sensing to Disease

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuliProvides a review of diseases with known or purported mechanobiological underpinningsIncludes the role of mechanobiology in tissue engineering and regenerative medicineCovers experimental methods to capture mechanobiological phenomena

Section 1: Mechanobiological basis of diseases 1.1 Osteoporosis 1.2 Cardiovascular mechanics and disease 1.3 Glaucoma and eye diseases 1.4 Growth and development 1.5 Tissue engineering and regenerative medicine

Section 2: Cellular basis of Mechanobiology 2.1 Cells as strain gages and load cells 2.2 Cell – extracellular matrix interactions 2.3 Mechanobiological pathways 2.4 Mechanically mediated epigenetics

Section 3: Experimental methods 3.1 Effects of shear stress on cells 3.2 Three-dimensional culture systems 3.3 Bioreactors 3.4 Tissue and organ on a chip systems

Section 4: Computational simulations in mechanobiology 4.1 Cell aggregation 4.2 Growth models 5. Future prospects and challenges 6. Bibliography 7. Glossary