Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.

Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.

Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disordersAdopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

1. Impact of Genome Plasticity on Health and Disease

Section I. Plasticity of the Human Genome 2. Overview of the Human Genome 3. Methods for Epigenomic Analyses: DNA Methylation 4. Genomic Databases 5. Genomic Variability: Germline, Somatic and de novo Variants 6. Founder Variations in Isolated Populations 7. DNA Methylation 8. Chromatin, Histones and Histone Modifications in Health and Diseases 9. Networks of Transcription Factors 10. Centromere and Telomere Dynamics in Humans

Section II. Human Genome Plasticity and Diseases 11. Genome Plasticity and Cardiovascular Diseases 12. Genome Plasticity and Neuropsychiatric Disorders 13. Genome Plasticity and Endocrine Diseases 14. Implications of Genome Plasticity for Drug Development