Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases.

Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.  

Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Foreword Una Macleod

Part I: Oxidative stress and neurological diseases

1. The role of reactive oxygen species in the pathogenic pathways of depression Masakazu Ibi and Chihiro Yabe-Nishimura

2. The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress David Fisher and Olufemi A. Alamu

3. Neuroinflammatory processes and oxidative stress Tameka A. Clemons, Na’Taki Osborne Jelks, L. Monique Vance, and Kimberly Williams

4. Revisiting the oxidative stress theory of aging: Molecular mechanisms underlying brain aging Joana C. d’Avila

5. Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration Anthea Di Rita and Flavie Strappazzon

6. Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation David Agustin León Navarro, María Crespo, and Mairena Martín

7. DJ-1 in astrocytic neuroprotection to oxidative stress Amanda J. Edson, Helena A. Hushagen, and Kari E. Fladmark

8. Oxidative stress markers in seizures and epilepsy: Methods and applications to models Laura Medina-Ceja, Kenia Pardo-Peña, and Alberto Morales-Villagrán

Part II: Antioxidants and neurological diseases

9. Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants Miguel Pinto, Sofia Benfeito, Carlos Fernandes, and Fernanda Borges

10. Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil Asmaa Badreddine, Amira Zarrouk, Wiem Meddeb, Thomas Nury, Leila Rezig, Meryam Debbabi, Fatima Zohra Bessam, Fatiha Brahmi, Anne Vejux, Mondher Mejri, Boubker Nasser, and Gérard Lizard

11. Aromatic plants: A source of compounds with antioxidant and neuroprotective effects Sandra Gonc¸alves, Inês Mansinhos, and Anabela Romano

12. The elderly, use of antioxidants and memory William K. Summers

13. Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues Dayane Pessoa de Araújo and Glauce Socorro de Barros Viana

14. Berberine neuroprotection and antioxidant activity Mohsen Imenshahidi and Hossein Hosseinzadeh

15. Carnosic acid and carnosol: Neuroprotection and the mitochondria Marcos Roberto de Oliveira

16. Coconut oil and antioxidative neuroprotection Siong Meng Lim, Nur Syafiqah Rahim, and Kalavathy Ramasamy

17. Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders Bibi Marjan Razavi and Hossein Hosseinzadeh

18. Neuroprotective mechanisms of Ginkgo biloba against oxidative stress Hoi Man Cheung and David Tai Wai Yew

19. Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection Vijayapandi Pandy, Srinivasa Reddy Bonam, Anji Reddy Raya, and Rama Rao Nadendla

20. Naringin and naringenin in neuroprotection and oxidative stress Pauline Maciel August and Bernardo Gindri dos Santos

21. Nigella sativa L. and thymoquinone as neuroprotective antioxidants Alireza Tavakkoli and Hossein Hosseinzadeh

22. Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol Christian Griñán-Ferré, Vanesa Izquierdo, and Mercè Pallàs

23. The role of saffron and its main components on oxidative stress in neurological diseases: A review Marjan Nassiri-Asl and Hossein Hosseinzadeh

24. Sulforaphane and its modulation of brain redox status: The mitochondria as a target Marcos Roberto de Oliveira

25. Recommended resources for oxidative stress and dietary antioxidants in neurological diseases Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy

Index