Protein Misfolding

Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more.

Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disordersContains timely chapters written by well-renowned authorities in their fieldProvides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students

1. Theoretical and computational advances in protein misfolding Parbati Biswas 2. Combining molecular dynamics simulations and experimental analyses in protein misfolding Holger Wille, Lyudmyla Dorosh, Sara Amidian, Gerold Schmitt-Ulms, and Maria Stepanova 3. Mass spectrometric approaches for profiling protein folding and stability Joseph C. Genereux 4. The intrinsic and extrinsic factors that contribute toproteostasis decline and pathological protein misfolding 145 Elise A. Kikis 5. Functional and dysfunctional folding, association andaggregation of caseins John A. Carver and Carl Holt 6. Protein misfolding in endoplasmic reticulum stress with applications to renal diseases Samera Nademi and Jeffrey G. Dickhout 7. Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics Christiane Mendre and Bernard Mouillac 8. LOXL1 folding in exfoliation glaucoma Audrey M. Bernstein, Robert Ritch, and J. Mario Wolosin 9. Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases 289 Guilherme A.P. de Oliveira, Yraima Cordeiro, Jerson L. Silva, and Tuane C.R.G. Vieira 10. Cytotoxic species in amyloid-associated diseases: Oligomers or mature fibrils Mohammad Khursheed Siddiqi, Sadia Malik, Nabeela Majid, Parvez Alam, and Rizwan Hasan Khan 11. Misfolded proteins as a therapeutic target in Alzheimer’s disease S. Imindu Liyanage, Donald F. Weaver 12. Influence of the reducing environment in the misfolding of wine proteins Paolo Ruzza, Claudia Honisch, Matteo Marangon, Andrea Curioni, Alan Bakalinsky, and Simone Vincenzi