Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function,  learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.

Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics fieldDescribes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafishFeatures examples of zebrafish models of human central nervous system disordersDiscusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Section I. Introduction to Zebrafish: Natural Habitat, Ethology, and Appropriate Maintenance Conditions 1. The biotic and abiotic environment of zebrafish 2. Maintenance and breeding of zebrafish, with some ethological and ecological considerations in mind

Section II. The Behavior of the Fry 3. The larval visual system and behavioral responses to visual stimuli 4. Visual escape in larval zebrafish: Stimuli, circuits, and behavior 5. Functional review of hearing in zebrafish 6. The development of social behavior 7. Classical and operant conditioning in larval zebrafish

Section III. The Behavior of the Adult 8. Motor patterns and swim path characteristics: the ethogram of zebrafish 9. Behavioral criteria and techniques to define sleep in zebrafish 10. Fear responses and antipredatory behavior of zebrafish: A translational perspective 11. Social behavior and its psychopharmacological and genetic analysis in zebrafish 12. Associative and non-associative learning in adult zebrafish 13. Relational learning in zebrafish: A model of declarative memory in humans?

Section IV. Genetic Methods for Zebrafish 14. Molecular genetic approaches to dissect complex behaviors in zebrafish 15. Behavioural research in zebrafish (Danio rerio): strain as source of variation 16. Designer mutants for behavioral genetics 17. Optogenetics 18. The CRISPR/Cas system in zebrafish 19. PhOTO Zebrafish and primed conversion: Advancing the mechanistic view of development and disease

Section V. Disease Models and Behavior Genetic Applications 20. Acute and chronic alcohol effects in zebrafish 21. Behavioural genetics of embryonic ethanol exposure in zebrafish: A model for FASD 22. Life, death, and regeneration of zebrafish dopaminergic neurons 23. Parkinson's Disease 24. Seizures and epilepsy 25. Aging, circadian clock and neurogenesis: the zebrafish approach 26. Modeling autism spectrum disorders in zebrafish 27. Studying aggression in zebrafish 28. Methylmercury induces transgenerationally transmissible epigenetic changes influencing zebrafish behavior

Section VI. Big Data and Bioinformatics 29. The design of behavioral screening in zebrafish 30. Software tools for behavioral phenotyping of zebrafish across the life span 31. The Zebrafish Genome Sequencing Project: Bioinformatics resources 32. Registered, standardized, and interactive: a review of online resources for zebrafish neuroanatomy