Organ-on-a-chip: Engineered Microenvironments for Safety and Efficacy Testing

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described.

Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.

Includes case studies of other organs on a chip that have been developed and successfully usedProvides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicinePresented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

1. Need for alternative testing methods and opportunities for organ-on-a-chip systems 2. Cell sources and methods for producing organotypic in vitro human tissue models 3. Organs-on-a-chip engineering

Part I Organ-on-a-chip platforms to model disease pathogenesis 4. Lung-on-a-chip platforms for modeling disease pathogenesis 5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease 6. Brain-on-a-chip systems for modeling disease pathogenesis 7. Kidney-on-a-chip 8. Heart-on-a-chip 9. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping 10. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment 11. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems

Part II Multi-organs-on-a-chip platforms to mimic humans physiology 12. Design and engineering of multiorgan systems 13. 8.b. Human body-on-a-chip systems 14. Automation and opportunities for industry scale-up of microphysiological systems 15. How to build your multiorgan-on-a-chip system: a case study