Principles of Tumors: A Translational Approach to Foundations

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology.

This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.

Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compoundsPresents translational approaches for every topic to improve conceptual insights for new research projectsCovers a broad range of subjects, making it easier for the reader to understand related fieldsIncludes diagrams for complex topics to aid in understanding for non-specialists

1. Introduction 2. Theories and definitions of tumors 3. Etio-pathogenesis of tumors 4. Growth of cells, growth factors and oncogenes 5. Hereditary Predispositions to Tumors, Tumor Suppressor Genes, and their Clinico-Genomic Complexities 6. The tumor types: the complexities in the combinations and variabilities of their traits 7. Epidemiology of Tumors 8. Aspects of the prevention of tumors 9. Clinical features of tumors 10. Morphologic assessment of cases of tumors 11. Endoscopic Visualisation and Imaging in Diagnosis and Assessments of cases of Tumors 12. Principles of surgery for tumors 13. Principles of non-surgical therapies 14. Aspects of radiation therapy 15. Specific aspects of cytotoxic and hormonal drug therapies 16. Immunological therapies 17. Gene Therapies not Related to Immunological Therapies 18. Other Therapies 19. Care after primary treatment 20. Costs, ethics and Malpractice Litigation

Appendix 1. Principles of normal histology and related cell biology 2. The normal genome 3. Fixed Genomic Events and Possible Mechanisms of their Causation by Etiological Agents 4. Genomic instabilities in Tumor Cells and the Immortality of Tumor Cell Populations 5. Methods in Histologic and Molecular Assessments of Tumors 6. Biomarkers in Epidemiology, Molecular Pathology and Oncology 7. Sub-lethal injuries and deaths of cells and tissues 8. Pretarget, Target and Recovery Defences of Cells Against Carcinogens and Cytotoxic Agents 9. Developing New Therapies