Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseasesContains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information providedIncludes contributions from recognized experts in the field

1. Protein intrinsic disorder and structure-function continuum Vladimir N. Uversky 2. Intrinsic disorder associated with 14-3-3 proteins and their partners Nikolai N. Sluchanko and Diego M. Bustos 3. Intrinsically disordered proteins and phenotypic switching: Implications in cancer Vivek Kulkarni and Prakash Kulkarni 4. Translational diffusion of unfolded and intrinsically disordered proteins Irina V. Nesmelova, Daria L. Melnikova, Venkatesh Ranjan and Vladimir D. Skirda 5. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans Anamika Avni, Hema M. Swasthi, Anupa Majumdar and Samrat Mukhopadhyay 6. Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases Orkid Coskuner and Vladimir N. Uversky 7. Shear-induced amyloid formation of IDPS in the brain Conrad N. Trumbore 8. Role of intrinsic disorder in muscle sarcomeres Dmitri Tolkatchev, Garry E. Smith Jr. and Alla S. Kostyukova 9. Computational prediction of functions of intrinsically disordered regions Akila Katuwawala, Sina Ghadermarzi and Lukasz Kurgan 10. The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins Neha Garg, Prateek Kumar, Kundlik Gadhave and Rajanish Giri