The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon.

Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it.

Reviews the neurobiological and cellular mechanisms of the sleep-wake cycleProvides the implications of sleep in health and diseaseContrasts different techniques to study molecular mechanismsContains case studies to better illustrate pointsCovers sleep disturbance and health problems involved in sleepIncludes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation

1. The Sleep-Wake Cycle. An Overview 2. Multiple experimental approaches for studying the sleep-wake cycle 3. Phylogeny of Sleep 4. Neuromolecular Mechanism for Sleep Generation 5. Physiological Mechanism for Control of Waking 6. Pharmacology of Sleep 7. Electrophysiological correlates of the sleep-wake cycle 8. Sleep Disturbances 9. Obesity and sleep disturbances 10. Alcoholism and sleep