Transgenerational Epigenetics

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born.

This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancerExamines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discoveryFeatures chapter contributions from international experts

1. Generational epigenetic inheritance

SECTION I Definitions and history of generational epigenetic inheritance 2. Definition of epigenetic transgenerational inheritance and biological impacts 3. Historical perspective of transgenerational epigenetics

SECTION II Germline epigenetics 4. Epigenetic changes in the mammalian paternal germ line

SECTION III Parental epigenetic inheritance 5. Maternal epigenetic inheritance 6. Paternal epigenetic inheritance

SECTION IV Basic mechanisms/processes of epigenetic inheritance 7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice 8. Histone-mediated transgenerational epigenetics 9. Heritable generational epigenetic effects through small noncoding RNA 10. Long noncoding RNA and epigenetic inheritance

SECTION V Model organisms 11. Nonmammalian model organisms in epigenetic research:an overview 12. Plant models of transgenerational epigenetic inheritance 13. Epigenetics and heritable phenotypic variations in livestock 14. Transgenerational epigenetic inheritance in insects

SECTION VI Evolution of transgenerational epigenetics 15. Evolutionary perspectives on transgenerational epigenetics 16. Inheritance of epigenome variants across generations during evolution

SECTION VII Environmental epigenetic effects on the offspring 17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals 18. Transgenerational effects of imprinting 19. Epigenetic inheritance across multiple generations

SECTION VIII Impact of transgenerational epigenetics on disease 20. Transgenerational epigenetics, paternal obesity, and insulin resistance 21. Epigenetic inheritance of type 2 diabetes

SECTION IX Clinical significance of transgenerational epigenetics 22. Clinical aspects of transgenerational epigenetics