Fibroblast Growth Factors

Fibroblast Growth Factors (FGFs) are a family of growth factors. They are involved in wound healing, angiogenesis, embryonic development, and endocrine signalling pathways. Fibroblast Growth Factors presents research and results from the leading research group on FGF globally, providing up to date and comprehensive coverage of this field. The book describes the history, basic research and growth engineering technology involved with FGFs, and introduces detailed research methods. The book comprises eight chapters. It details successes and problems in relation to wound healing of engineered growth factors, and consider injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. This is a key book for researchers working on FGFs.

Focusses on growth engineering aspects of FGF-based drug development and clinical applicationPresents useful information on the history of FGFs, and basic research and growth engineering technologyProvidesdetailed and practical research methods and results obtained on FGFsConsiders successes as well as problems in engineering technology involved with FGFsOffers up to date and comprehensive coverage from the world’s leading research group

1. Engineered growth factor review
2. FGFs in injury repair and regeneration
3. FGF non-mitogenic mutants
4. Pathophysiology and Pharmacology of FGFs
5. FGFs in embryonic development and reproductive functions
6. Design and discovery of FGF/FGFR inhibitors
7. Protein structure and modification of FGFs
8. Bioengineering of FGFs and new drug developments