Genetics, Neurology, Behavior, and Diet in Parkinsons Disease: The Neuroscience of Parkinson’s Disease, Volume 2

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendationsServes as a "one-stop" source for everything you need to know about Parkinson’s disease

Part I: Genetics, molecular and cellular biology

2. Alpha-synuclein gene and Parkinson’s disease Athina-Maria Simitsi, Chistos Koros and Leonidas Stefanis

3. The DJ-1 gene and protein: links with Parkinson’s disease Vanessa J. Musco, Sarah J. Annesley and Paul R. Fisher

4. Regulation of tyrosine hydroxylase: relevance to Parkinson’s disease Gelareh Alam and Jason R. Richardson

5. Linking glucocerebrosidase gene (GBA) variants and Parkinson’s disease ctoria Berge-Seidl and Mathias Toft

6. Astrocytes and microglia in Parkinson’s disease and animal models Katarzyna Kuter

7. The role of autophagy in Parkinson’s disease etiopathogenesis Emanuel Candeias, Jãao Duarte Magalhães, Daniel Santos, Helena Costa, Diana F. Silva, Ana Raquel Esteves and Sandra Morais Cardoso

8. The mitochondrial network in Parkinson’s disease Andreas Aufschnaiter, Verena Kohler and Sabrina Büttner

9. Signal transduction in Parkinson’s disease: modulation of neurotransmission, symptomatology, and therapy Mattia Volta

10. Oxidative stress signaling and regulated cell death in Parkinson’s disease Carlos Velez-Pardo and Marlene Jimenez-Del-Rio

11. Subcellular-specific alpha-synuclein in Parkinson’s disease Benjamin Rosen, Ketan S. Patil, Guido W. Alves and Simon G. Møller

12. Melanocortin 1 receptor: Parkinson’s disease, melanoma risk, and neuroprotection Gemma Tell-Marti, Joan Anton Puig-Butillé and Susana Puig

13. Energy regulation and Parkinson’s disease Liting Hang and Kah-Leong Lim

14. Linking rotigotine, Parkinson’s disease, and brain-derived neurotrophic factor Kazuhiro Sohya, Kazunori O’Hashi and Hiroshi Kunugi

Part II: Neurology, physiology and imaging

15. The different syndromes in Parkinson’s disease: an overview Nikolaos Giagkou and Maria Stamelou

16. Neuromolecular imaging in Parkinson’s disease Patricia A. Broderick and Leslie Wenning

17. Interlinking brain mapping and Parkinson’s disease: MRI analysis, nigrosome 1 and nigrosome 4 Eung Yeop Kim, Young Hee Sung and Jongho Lee

18. Interconnecting Parkinson’s disease: the use of computed tomography and microelectrode recording in DBS surgery Ryan B. Kochanski and Sepehr Sani

19. Linking diffusion tensor imaging, microstructures and Parkinson’s disease Yu Zhang, Norbert Schuff, I-Wei Wu and Duygu Tosun

20. Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRI Jason Langley, Daniel E. Huddleston and Xiaoping P. Hu

21. Vagal motoneurons in Parkinson’s disease Ruth E. Musgrove, Wei-Hua Chiu and Joshua A. Goldberg

22. Circadian clock disruption and neuroinflammation in Parkinson’s disease: a new perspective Elisabetta Lauretti and Domenico Praticò

23. Motor cortex stimulation in Parkinson’s disease Angelo Lavano, Giusy Guzzi, Attilio Della Torre and Domenico La Torre

24. Action programming disorders associated with Parkinson’s disease Kenneth M. Heilman

25. The striatal medium spiny neurons: what they are and how they link with Parkinson’s disease Fu-Ming Zhou

26. Disruptions of frontostriatal language functions in Parkinson’s disease Adolfo M. García, Yamile Bocanegra, Agustina Birba, Juan Rafael Orozco-Arroyave, Lucas Sedeño and Agustín Ibañez

27. Alpha-synuclein and neuroinflammation in Parkinson’s disease Tatiana Varanita and Luigi Bubacco

28. Tau and its interactions with other proteins in neurodegenerative diseases Katelyn H. Mroczek, Sarah J. Annesley and Paul R. Fisher

29. Interaction between brain angiotensin and dopaminergic systems and Parkinson’s disease Jose Luis Labandeira-Garcia, Pablo Garrido-Gil, Maria A. Pedrosa, Carmen M. Labandeira and Ana I. Rodriguez-Perez

30. Restoring dopamine levels in Parkinson’s disease: neuronal pathways, agonists and antiinflammatory agents Ágatha Oliveira-Giacomelli, C.M. Albino, Hellio Danny Nóbrega de Souza and Henning Ulrich

Part III: Behaviour and psychopathology 

31. Motivation and motivational aspects of Parkinson’s disease Abdeslam Chagraoui, Emilie Puginier and Philippe De Deurwaerdère

32. Linking anxiety, cognitive and sensory deficits to gait and balance deficits in Parkinson’s disease Quincy J. Almeida

33. Motor programs interlinking gait and bradykinesia in Parkinson’s disease Tateo Warabi, Kiyoharu Inoue and Nobuo Yanagisawa

34. Olfactory disturbances in Parkinson’s disease Lais S. Rodrigues, Juliane Fagotti, Adriano D.S. Targa, Ana Carolina D. Noseda, Jessica L. Ilkiw, Flavia W.C. Dorieux and Marcelo M.S. Lima

35. Interlinking dementia in Parkinson’s disease: nutritional correlates of body composition Arthur Oscar Schelp, Jéssica Emy Komuro, José Eduardo Corrente and Silvia Justina Papini

36. The role of the gastrointestinal system and gut microbiota in Parkinson’s disease Jade Kenna and Ryan S. Anderton

37. Swallowing impairment in Parkinson’s disease Maira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

38. The Mini Nutritional Assessment (MNA) and applications to Parkinson’s disease Svetlana Tomic

39. The efficacy of Bacopa monnieri extract in modulating Parkinson’s disease Dr. Ravikumar Hosamani

Part V: Models, modelling and resources

40. 6-hydroxydopamine-induced model of Parkinson’s disease Katarzyna Kaczyńska and Kryspin Andrzejewski

41. Knockdown transgenic Drosophila and Parkinson’s disease Marlene Jimenez-Del-Rio and Carlos Velez-Pardo

42. Neuroprotection in animal models of Parkinson’s disease: exploring exercise, sound, and light John Mitrofanis

43. Modeling with the A53T α-synuclein model of Parkinson’s disease Thomas Musacchio, James B. Koprich and Chi Wang Ip

44. Linking the leucine-rich repeat kinase 2 gene, animal models, and Parkinson’s disease Yulan Xiong and Jianzhong Yu

45. Neuroscience of Parkinson’s disease: recommended reading and resources Rajkumar Rajendram, Vinood B. Patel and Victor R. Preedy