Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understandingProvides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Section 1 Dementia: Introductory Chapters  1. A review of the different types of dementia 2. The classification of dementia: problems and challenges 3. Alzheimer’s disease: an overview 4. Dementia and competing hypothesis – the example of Alzheimer’s disease and its various hypotheses 5. Lewy body dementia – an overview 6. Mixed dementia – an overview 7. Vascular dementia – an overview 8. Linking in physical activity and dementia 9. Risk factors in dementia 10. Mortality in dementia – linking in delirium 11. Rare forms of dementia 12. Prion diseases and dementia 13. Dementia in Parkinson disease 14. Dementia in traumatic brain injury 15. Risk factors in dementia – towards a coherent theory of dementia 16. Genetics of dementia

Section 2 Biomarkers, Psychometric Instruments, and Diagnosis  17. Circulating biomarkers in neurodegenerative dementias – YKL-40 and beyond 18. Salivary biomarkers in Alzheimer’s disease 19. Use of cerebrospinal fluid in diagnosis of dementias 20. SPECT perfusion imaging in assessment of neurodegenerative dementias 21. Computerised tomography (CT) in assessment of neurodegenerative dementias 22. Magnetic resonance imaging (MRI) in assessment of neurodegenerative dementias 23. Questionnaires: The mini-mental state examination (MMSE) and beyond 24. The Cambridge Mental Disorders of the Elderly Examination (CAMDEX) and applications to dementia 25. The Montreal Cognitive Assessment (MoCA) and applications to dementia 26. The Hopkins Verbal Learning Test (HVLT) and applications to dementia 27. The Addenbrooke’s Cognitive Examination (ACE) and applications to dementia 28. ALBA Screening Instrument (ASI) and applications to dementia 29. The prediction of Alzheimer’s disease

Section 3 Pharmacological Treatments for Dementia 30. Cholinesterase inhibitors in dementias – an overview 31. NMDA receptor antagonists in dementia – an overview 32. Donepezil usage – a focused review 33. Rivastigmine usage – a focused review 34. Galantamine usage – a focused review 35. Memantine – a focused review 36. Failures and successes of monoclonal antibodies – bapineuzumab and beyond 37. Immunotherapies: an overview

Section 4 Non-Pharmacological Treatments 38. Internet counselling 39. Counselling in dementia 40. Cognitive rehabilitation in dementia 41. Cognitive stimulation in dementia 42. Anodal Transcranial Direct Current Stimulation 43. Nanoparticles: nanodiamond treatment in Alzheimer’s disease 44. Increasing intakes and improving nutritional status in dementia 45. All-trans retinoic acid in Alzheimer’s disease 46. Environmental enrichment in dementia 47. Music therapy in dementia 48. Aromatherapy in dementia 49. Massage in dementia 50. Dancing in dementia 51. Multisensory Stimulation in Dementia 52. Animal-assisted therapy in dementia 53. Occupational therapy in dementia