Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials.

This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.

Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailmentsCovers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivoExamines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

1. Introduction to Cell Biology
2. Physiology of Cellular Demise
3. Molecular Pathways of Apoptotic Cell Death
4. Apoptosis: Warrior or Opponent
5. Protocols in apoptosis identification and affirmation
6. Modulating apoptosis in cancer
7. Cardiovascular diseases
8. Recent approaches to target apoptosis in neurological disorders
9. Autoimmune diseases and apoptosis: targets, challenges and innovations
10. Clinical trials of promising apoptosis modulating drugs