Intracellular Signalling Proteins

Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more.

Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanismsTargeted to a very wide audience of specialists, researchers and studentsContains timely chapters written by well-renowned authorities in their fieldIncludes a number of high quality illustrations, figures and tables

1. Voices from the dead: The complex language and intricate grammar of dead cells Jerrold S. Levine and David S. Ucker 2. Nucleobindins and encoded peptides: From cell signaling to physiology Adelaine Leung, Naresh Ramesh, Christine Vogel and Suraj Unniappan 3. Estrogen receptor signaling mechanisms Nathalie Fuentes and Patricia Silveyra 4. Intracellular signaling of the AMP-activated protein kinase Miribane Dërmaku-Sopjani and Mentor Sopjani 5. Relationship between mitofusin 2 and cancer Alessandro Allegra, Vanessa Innao, Andrea Gaetano Allegra and Caterina Musolino 6. Molecular signaling in bone cells: Regulation of cell differentiation and survival Lilian I. Plotkin and Angela Bruzzaniti 7. Activating mutations of the gp130/JAK/STAT pathway in human diseases Juliane Lokau and Christoph Garbers 8. Aquaporin water channels: New perspectives on the potential role in inflammation Margherita Sisto, Domenico Ribatti and Sabrina Lisi 9. Intracellular protein complexes involved in synapse assembly in presynaptic neurons Kyung Ah Han, Ji Won Um and Jaewon Ko 10. Dopamine signaling in the striatum Emmanuel Valjent, Anne Biever, Giuseppe Gangarossa and Emma Puighermanal 11. Recent advances in computational studies of GPCR-G protein interactions Jinan Wang and Yinglong Miao 12. From traveler to homebody: Which signaling mechanisms sponge larvae use to become adult sponges? Ilya Borisenko, Olga I. Podgornaya and Alexander V. Ereskovsky