Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets

Viral polymerases constitute a vital component in the life cycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favourable targets for the design and development of antiviral drugs. The most dangerous viruses, threatening the life of human beings and containing polymerases, have been the hepatitis viruses (particularly B and C), herpesviruses, HIV, and influenza virus. Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth studies made on the structure and functions of polymerases and their roles in life cycle of viruses and as drug targets

Provides comprehensive, state-of-the-art coverage of virus infections, the virus life cycle, and mechanisms of polymerase inhibition Analyses structure-activity relationships of inhibitors of each viral polymerasePresents a consistent and comprehensive coverage of all aspects of viral polymerases, such as structures, functions and their roles as antiviral drug targets

1. RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy 2. Structure-Function Relationship of Negative-Stranded Viral RNA Polymerases: Prospectives for Antiviral Therapy 3. RNA-Dependent RNA Polymerase of Alphaviruses: A Potential Target for the Design of Drugs Against Alphaviruses 4. DNA-dependent DNA Polymerases as Drug Targets in Herpesviruses and Poxviruses 5. Polio Virus Polymerase: An Effective Target for Design and Development of Anti-polio Drugs 6. Studies on HIV-1 Polymerase and its Inhibitors 7. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics 8. Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase: An Integral Part of HCV Antiviral Therapy 9. HBV Polymerase as a Target for Development of Anti-HBV Drugs 10. Polymerases of Coronaviruses: Structure, Function and Inhibitors 11. Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors 12. Herpes Virus Polymerase Inhibitors 13.  Zika Virus Polymerase: Structure, Function and Inhibitors 14. Dengue Virus Polymerase: A Crucial Target for Anti-Viral Drug Discovery 15. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics