Epigenetics and Regeneration

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming.

As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics.

Provides a foundational overview of epigenetics in regenerative medicineExamines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practiceOffers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathwaysFeatures chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

1. Epigenetics and Regeneration: An Overview

Section I: Epigenetics: molecular players and mechanisms 2. Dynamics and mechanisms of DNA methylation reprogramming 3. Histone modifications 4. Non-coding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation 5. Organizing Principles for the Spatial Folding of Chromosomes

Section II: Development, Reprogramming & Tissue regeneration 6. Epigenetics of early mammalian development: A Pathway to Regenerative Medicine 7. Somatic Cell Epigenetic Reprogramming: Molecular Mechanisms and Therapeutic Potential 8. Regenerative potential across species: An Eco-Evo-Devo Perspective

Section III: Regenerative medicine: The epigenetics of tissue homeostasis, repair and regeneration 9. Common challenges in tissue regeneration 10. Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration 11. Transcriptional and Epigenetic Mechanisms Controlling Intestinal Cell Fate 12. Using Epigenetics as a Pharmacological Tool in Heart Regeneration 13. Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease 14. The Intrinsic Role of Epigenetics in Axonal Regeneration 15. Insights Into the Epigenetics of Retinal Development and Diseases 16. At the Intersection of Epigenetics and Regeneration: An Analysis of the Experimental Outlook of Organoid Technology

Section IV: Epigenetics, regeneration and environment 17. Epigenetic pharmacology in regenerative medicine (epi-drugs) 18. Genomic and Epigenomic Potential With Age: Genome, Epigenome, and the Epigenetic Clock 19. Epigenetics and Lifestyle: The Impact of Stress, Diet, and Social Habits on Tissue Homeostasis20.

Section V: Conclusive Remarks 20. iPSC- and Organoid-Based Biomedicine at the Intersection of Epigenetics and Regeneration: Charting the Normative Contours of Emerging Biomedical Platforms