Fundamentals of Molecular Structural Biology

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.

Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advancesAddresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biologyPresents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

1. Introduction - A historical perspective
2. Mathematical tools
3. Physical basis of chemistry
4. Chemical basis of biology
5. Biomacromolecules
6. Structure analysis and visualization
7. Protein folding
8. DNA synthesis: Replication
9. Transcription
10. RNA processing
11. Translation
12. DNA damage and repair
13. Recombination
14. Membrane structure and function
15. Fundamentals of structural genomics
16. Cell signaling and systems biology
17. Macromolecular assemblies
18. Computational molecular biology