Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis, Volume 14, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project.

Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world.

Presents state-of-the-art developments in organic synthesisProvides insight and offers new perspective to problem-solvingWritten by leading experts in the fieldUses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

1. Total Synthesis of (−)-α-Cyclopiazonic Acid: A Study in Perseverance
2. Synthesis of Types II and III Post-Iboga Alkaloids
3. Total Syntheses of Caloundrin B and its Putative Precursor, and Their Transformations into Siphonarin B, Baconipyrone A, and Baconipyrone C
4. Integration of Novel Strategy and Methods: Total Synthesis of Antitumor Lasonolide A
5. Enantiospecific Total Synthesis of the Sesterterpenoid Astellatol
6. Total Synthesis of (±)-Cephanolides B and C Enabled by Palladium-Catalyzed Cascade Cyclization and Late-Stage sp3 C-H Bond Oxidation
7. A Dual C-H Functionalization Strategy for the Total Synthesis of Tambromycin
8. Trithiol Compounds – Tricky but Valuable: The Design and Synthesis of Ligands for Stabilizing Radioarsenic for Radiopharmaceutical Development
9. Synthesis of Theoretically Interesting Molecules
10. Asymmetric Synthesis of (+)-Laurencin using a Stereoselective Stevens [1,2]-Shift of Sulfonium Ylide