The Value of BCG and TNF in Autoimmunity

The Value of BCG (Bacille de Calmette et Guérin) and TNF (tumor necrosis factor) in Autoimmune Diseases, Second Edition provides an overview of current research and thinking related to TNF induction and use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and the first book (2014) the field of BCG research has grown considerably. The new edition will have updates to the "Old Friends", MS and diabetes chapters, but also feature at least eight additional chapters that reflect new prevention and treatment trials in autoimmunity and allergy as well as a new understanding of the genetics of BCGs mechanisms of action.

Brings into one resource the international scientific literature on a unique way and provides a different perspective on treatment approaches for certain autoimmune conditionsGives insight into the how the BCG vaccine impacts gene expression and the durability of the BCG vaccines in long lasting clinic effectsDiscusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatmentEditor awarded 2005: Oprah Achievement Award," Top Health Breakthrough by a Female Scientist"Covers new topics like: New topics that will be covered: Epigenetics of tuberculosis, BCG in neurological disease, BCG in early childhood and allergy, BCG in large prevention trials, Gene expression of BCG and re-methylation of genes, BCG and public health issues, BCG effects of the immune response and cytokine response in humans

1. BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease 2. The Potential of TNF Induction from BCG for the Treatment of Type 1 Diabetes 3. Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation 4. Host Epigenetic Modifications in Mycobacterium Tuberculosis Infection: A Boon or Bane 5. Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy 6. The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity 7. BCG in Neonatals 8. Epigenetic Rewiring of Monocytes in BCG Vaccination 9. Mycobacteria, Immunoregulation and Autoimmunity 10. mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium Tuberculosis Infection and BCG Vaccination 11. The Role of Maternal Priming and Boosting for the Non-Specific Effects of BCG Vaccine