Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects

This completely updated and expanded second edition of Systemic Lupus Erythematosus; Basic, Applied and Clinical Aspects includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter will be short and will be presented critically and not in an encyclopedic manner and with selected, up to 50, references which should be valuable to a wider audience. As a seasoned (not old) editor, he worked with practically all the contributors and this enables to achieve the goals of the book. This manual to SLE combines basic science with clinical science to provide a translational treatment of the disease. Systemic Lupus Erythematosus, a Manual, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

This new edition includes new chapters on:

Microbiota and lupus by Dr. Greg Silverman- a pioneer on this topic Innate immune cells and lupus Monogenic lupus

And includes also new techniques and ideas that have been developed for the study of the SLE process and related conform all invariant systems like couplings with Gaussian fields and the related "geometries", measures on loops, and new perspectives on CFT.

Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the diseaseIncludes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and moreConveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damageDiscusses the latest treatment options on disease modifying or disease controlling agentsProvides 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment

Part I - Epidemiology and diagnosis 1. History of systemic lupus erythematosus with an emphasis on certain recent major issues Shu Man Fu and Felicia Gaskin 2. The patient Donald E. Thomas, Jr. 3. A plea of a young patient to the lupus experts Brianna Fitzpatrick 4. Epidemiology Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcon 5. Measuring disease activity Joan T. Merrill 6. Disease development and outcome Mary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman 7. Socioeconomic aspects of SLE Titilola Falasinnu and Julia F. Simard 8. Biomarkers in systemic lupus erythematosus Stacy P. Ardoin and Wael N. Jarjour Part II - Pathogenesis 9. Overview of the pathogenesis of systemic lupus erythematosus Antonio La Cava 10. System lupus erythematosus and the environment Soad Haj Yahia and Nancy Agmon-Levin 11. Genes and genetics in human SLE Mara L. Lennard Richard and Betty P. Tsao 12. Monogenic lupus Mindy S. Lo 13. Hormones Takayuki Katsuyama and Vaishali R. Moulton 14. Clinical aspects of the complement system in systemic lupus erythematosus John P. Atkinson, M. Kathryn Liszewski and C. Yung Yu 15. T cells Florencia Rosetti and Jose C. Crispin 16. B cells in SLE Andreia C. Lino and Thomas Doerner 17. Neutrophils in systemic lupus erythematosus Amr H. Sawalha 18. The role of dendritic cells in systemic lupus erythematosus Manon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco 19. Cytokines Takayuki Katsuyama and Vaishali R. Moulton 20. RNA/DNA sensing in SLE-Toll-like receptors and beyond Caroline A. Jefferies and Amir Sharabi 21. The role of interferons in systemic lupus erythematosus Ruth Fernandez-Ruiz and Timothy Niewold 22. Fc receptors in autoimmunity and endorgan damage T. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas 23. Apoptosis, autophagy, and necrosis Roberto Caricchio 24. Infections in early systemic lupus erythematosus pathogenesis Rebecka Bourn, Samantha Slight-Webb and Judith A. James 25. Microbiota influences on systemic lupus erythematosus and Sjoegren's syndrome Teri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel 26. Origin of autoantibodies Westley H. Reeves, Shuhong Han and Haoyang Zhuang 27. Anti-DNA antibodies Susan Malkiel, Yemil Atisha-Fregoso and Betty Diamond 28. Antihistone and antispliceosome antibodies Minoru Satoh, Marvin J. Fritzler and Edward K.L. Chan 29. Immune complexes in systemic lupus erythematosus Keiju Hiromura and Masaomi Nangaku 30. MicroRNA in systemic lupus erythematosus Bo Qu, Xiaoyue Jiang and Nan Shen 31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycin Andras Perl 32. Epigenetics Christian M. Hedrich 33. What do mouse models teach us about human SLE? Ziaur S.M. Raman and Chandra Mohan 34. Genes and genetics of murine systemic lupus erythematosus Dwight H. Kono and Argyrios N. Theofilopoulos Part III - Mechanisms of tissue damage 35. Mechanisms of renal damage in systemic lupus erythematosus Shu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin 36. Mechanisms of vascular damage in systemic lupus erythematosus Sarfaraz A. Hasni and Mariana J. Kaplan 37. The mechanism of skin damage Xin Huang, Haijing Wu, Christopher Chang and Qianjin Lu 38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus David Hunt Part IV - Clinical aspects of the disease 39. Constitutional symptoms and fatigue in systemic lupus erythematosus Syahrul Sazliyana Shaharir and Caroline Gordon 40. The musculoskeletal system in SLE Maria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie 41. Cutaneous lupus erythematosus Annegret Kuhn, Aysche Landmann and Gisela Bonsmann 42. The clinical evaluation of kidney disease in systemic lupus erythematosus Brad H. Rovin, Isabelle Ayoub and Swati Arora 43. The pathology of lupus nephritis Isaac Ely Stillman 44. Cardiovascular disease in systemic lupus erythematosus: an update Stephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi 45. The lung in systemic lupus erythematosus Lindsy Forbess, Daniel J. Wallace and Caroline Jefferies 46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus Chi Chiu Mok 47. Systemic lupus erythematosus and infections Amy Devlin and Robert H. Shmerling 48. Malignancies in systemic lupus erythematosus Alexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky 49. The nervous system in systemic lupus erythematosus David Hunt 50. Overlap syndromes Eric L. Greidinger 51. Systemic lupus erythematosus and the eye Erika M. Damato, Philip I. Murray and Alastair K.O. Denniston 52. Fertility and pregnancy in systemic lupus erythematosus Bonnie L. Bermas and Lisa R. Sammaritano 53. Neonatal lupus Clinical spectrum, biomarkers, pathogenesis, and approach to treatment Jill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright 54. Incomplete lupus syndromes Nancy J. Olsen 55. Lupus in children Mindy S. Lo 56. Drug-induced lupus Robert L. Rubin 57. Vasculitis in lupus Anisur Rahman Part V - Antiphospholipid Syndrome 58. Pathogenesis of antiphospholipid syndrome Olga Amengual and Tatsuya Atsumi 59. Antibodies and diagnostic tests in antiphosholipid syndrome Cecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni 60. Clinical manifestations Miyuki Bohgaki and Takao Koike 61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosus Robert G. Lahita and Trina Pal 62. Value of antimalarial drugs in the treatment of lupus Fadi Hassan, Mohammad E. Naffaa and Ziv Paz 63. Systemic glucocorticoids Zahi Touma and Murray B. Urowitz 64. Cytotoxic drug treatment Eleni A. Frangou, George Bertsias and Dimitrios T. Boumpas 65. Treatment of antiphospholipid syndrome Savino Sciascia and Munther Khamashta 66. New treatments of systemic lupus erythematosus Vasileios C Kyttaris 67. Repositioning drugs for systemic lupus erythematosus Kathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer