Pharmaceutical Applications of Dendrimers

Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer.

This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery.

Explores the role of dendrimers in the design of dendritic nanoplatforms for targeted drug and gene delivery systemsDiscusses the potential of dendrimers in preformulation and formulation developmentAddresses both clinical and regulatory challenges in the development of dendrimer-based formulations

1. Dendrimers: Introduction, types and properties
2. Dendrimers as solubility enhancer or excipient
3. Dendrimers as therapeutic agent/drug
4. Biocompatibility and toxicity of dendrimers
5. Dendrimers as drug delivery carrier
6. Dendrimers for the delivery of biological drugs
7. Pharmacokinetic considerations in design of dendrimer-based nanomedicines
8. Design of dendrimer-based prodrugs
9. Stimuli-responsive dendrimers in drug delivery
10. Dendrimer-based targeted drug delivery
11. Dendrimers in photodynamic therapy
12. Diagnostic applications of dendrimer based nanovectors
13. Overview of current clinical status of dendrimer-based formulations