Nucleic Acid Nanotheranostics: Biomedical Applications

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.

Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areasCovers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimagingPresents the only book to include an analysis of nanoformulations approved for clinical use

1. Therapeutic oligonucleotides against cancer: Recent approaches and new perspectives 2. Small interfering RNA-mediated silencing of ribophorin II (RPN2) gene: The way forward for the treatment of malignant breast cancer 3. Non-coding RNAs in cardiovascular disease 4 MicroRNAs in respiratory diseases 5. State of the art and future direction for the analysis of cell-free circulating DNA 6. Aptamer-based strategies for diagnosis 7. Viral Vectors for Treatment of Human Disease: Therapeutic and Manufacturing Challenges 8. Nonviral nucleic acid therapy: Peptiplexes 9. Controlling Protein Expression by Delivery of RNA Therapeutics Using Lipid Nanoparticles 10. Advanced Polymers for Nonviral Gene Delivery 11. Nonviral Gene Therapy: Design and Application of Inorganic Nanoplexes 12. Extracellular vesicles as a novel nanocarriers for therapeutic delivery 13. Nanocarrier-based Gene therapy Imaging Strategies 14. The state-of-art of investigational and approved nanomedicine products for nucleic acid delivery