Protein-Protein Interactions in Human Disease, Part B

Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.

Describes advances in the application of powerful techniques in studying and analyzing protein-protein interactionsIdeal for a wide audience of researchers, specialists and studentsWritten by authorities in their fieldContains a number of high quality illustrations, figures and tables that support the presented information

1. Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design Sitanshu S. Singh and Seetharama D. Jois 2. Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years Old Alexander B. Sigalov 3. Targeting the Architecture of Deregulated Protein Complexes in Cancer Eduard Stefan, Jakob Troppmair and Klaus Bister 4. Multifaceted Nucleolin Protein and Its Molecular Partners in Oncogenesis Iva Ugrinova, Maria Petrova, Mounira Chalabi-Dchar and Philippe Bouvet 5. Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs Carlos Costas-Insua, Javier Merino-Gracia, Clara Aicart-Ramos and Ignacio Rodríguez-Crespo 6. Development of Protein–Protein Interaction Inhibitors for the Treatment of Infectious Diseases Andrew F. Voter and James L. Keck 7. Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions Manuel Llano and Mario A. Peña-Hernandez 8. Investigating the Influence of Hotspot Mutations in Protein–Protein Interaction of IDH1 Homodimer Protein: A Computational Approach D. Thirumal Kumar, P. Sneha, Jennifer Uppin, S. Usha and C. George Priya Doss 9. Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein–Drug Bipartite Network Javier De Las Rivas, Diego Alonso-López and Mónica M. Arroyo