Sphingolipids in Cancer

Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more.

1. Mechanisms of ceramide-dependent cancer cell death Rose Nganga, Natalia Oleinik and Besim Ogretmen 2. Sphingolipids as regulators of autophagy and endocytic trafficking Megan M. Young and Hong-Gang Wang 3. Role and function of sphingomyelin biosynthesis in the development of cancer Giovanni D’Angelo, Sitapriya Moorthi and Chiara Luberto 4. Neutral sphingomyelinases in cancer: friend or foe? Christopher J. Clarke 5. Ceramide and exosomes: a novel target in cancer biology and therapy Ahmed Elsherbini and Erhard Bieberich 6. Sphingolipids at the crossroads of NAFLD and senescence Mariana Nikolova-Karakashian 7. Ceramide signaling and p53 pathways Kristen Jeffries and Natalia Krupenko 8. The role of ceramide 1-phosphate in tumor cell survival and dissemination Antonio Gomez-Muñoz 9. The onus of sphingolipid enzymes in cancer drug resistance Samy A.F. Morad and Myles C. Cabot 10. Interdiction of sphingolipid metabolism revisited: focus on prostate cancer Christina Voelkel-Johnson, James S. Norris and Shai White-Gilbertson 11. Targeting sphingosine kinases for the treatment of cancer Clayton S. Lewis, Christina Voelkel-Johnson and Charles D. Smith 12. Novel sphingolipid-based cancer therapeutics in the personalized medicine era Jeremy Shaw, Pedro Costa-Pinheiro, Logan Patterson, Kelly Drews, Sarah Spiegel and Mark Kester 13. Side effects in cancer therapy: are sphingolipids to blame? Falak Patel and Stefka D. Spassieva